Project Overview
Project title: Deciphering the immuno-pathophysiology of cryptococcal disease across the spectrum
Abbreviation: Immuno-pathophysiology in the spectrum of cryptococcal disease (INSPECT-Crypto)
The INSPECT-Crypto project aims to elucidate the changes in predominant biomarkers of inflammation and brain injury in blood and CSF of patients along the spectrum of HIV-associated cryptococcal infection and disease. It is a mixed cross-sectional retrospective and prospective cohort study of 200 participants (5 groups of 40 per group) along the spectrum of cryptococcal infection/ disease.
Key Objectives
Primary Outcomes
The primary objective of the study is to elucidate the changes in predominant biomarkers of inflammation and brain injury in blood and CSF of patients along the spectrum of HIV-associated cryptococcal infection and disease.
Secondary Objectives
Exploratory Objectives
Achievements
Protocol approved by UCT HREC, UCT Faculty of Health Sciences Biosafety Committee, and Western Cape Department of Health. Not yet open to recruitment.
Current Status
Recruitment / Site Participation
Not yet started, pending a protocol amendment which will include additional sites outside of Cape Town.
Team Members
Media
First samples from EFFECT and Sub-EFFECT being processed in Dr Dangarembizi’s lab for generation of pilot data