Project Overview
Project title: Developing platforms for novel Pneumocystis pneumonia (PCP) diagnostics and treatments
Abbreviation: Pneumocystis pneumonia (PCP)
P. jirovecii is an opportunistic pathogen causing Pneumocystis pneumonia (PCP), increasingly recognised as an important cause of pneumonia in high HIV burden areas. Our systematic reviews have found a PCP prevalence of over 20% amongst HIV-infected inpatients presenting with respiratory symptoms in sub-Saharan Africa. HIV associated PCP outcomes are poor in sub-Saharan Africa. This prospective observational study consists of a programme of earlier-stage laboratory and clinical research into PCP, reflecting the relative underdevelopment of this research field.
This study involves the recruitment of individualised hospitalised with PCP in South Africa to a cohort that will yield high quality clinical data and materials to provide insights into this important disease and inform development of novel diagnostics and therapeutic approaches.
Key Objectives
Recruitment / Site Participation
150 Adult patients with advanced HIV and hypoxic pneumonia will be recruited at the Khayelitsha Hospital, Western Cape, South Africa.
Principal Investigators
Project Partners
Publications and Abstracts
CRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystis pneumonia diagnosis
Brady M. Youngquist, Ayanda Trevor Mnguni, Dora Pungan, Rachel PJ Lai, Guixiang Dai, Chun Fai Ng, Amy Samson, Yasmean Abdelgaliel, Christopher J. Lyon, Bo Ning, Shahid Husain, Sean Wasserman, Jay K. Kolls, and Tony Y. Hu